Differential sensitivity of cancer cells to docosahexaenoic acid–induced cytotoxicity: The potential importance of down-regulation of superoxide dismutase 1 expression Omega-3 (DHA)

Summary: The present study has examined the cytotoxic effects of DHA on five different human cancer cell lines and explored the potential cellular mechanisms explaining the different sensitivity among those cell lines. We show that a transformed large cell lymphoma cell line (DHL-4) is highly sensitive to DHA treatment and that, in these cells (but not in DHA-resistant lines), DHA alters the expression of SOD1, which suggests a mechanism that may contribute to the differential sensitivity of tumor cells to DHA